Nanosensor to detect biomarkers for Parkinson’s disease

Nanowerk reports on vertically aligned ZnO nanowire arrays on 3D graphene foam to selectively detect uric acid (UA), dopamine (DA), and ascorbic acid (AA). The application is detection of uric acid from the serum of Parkinson’s disease (PD) patients as abnormal levels of UA are symptomatic of several diseases, including gout, hyperuricemia, and Parkinson’s disease; and low levels of DA are related to neurological disorders such as PD and schizophrenia.

“UA, DA, and AA coexist in the extracellular fluid of the central nervous system and serum. However, it is difficult to simultaneously detect each species in a mixture with high selectivity and sensitivity when using conventional solid electrodes because their oxidation potentials overlap, the surface area is insufficient, and/or the kinetic accessibility of each species is limited.”


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